|The MBNL1 mbnl1 (Catalog #MBS608310) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Muscleblind-like 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA, Western Blot. Researchers should empirically determine the suitability of the MBNL1 mbnl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MBNL1 mbnl1 product has the following accession number(s) (GI #254039624) (NCBI Accession #NP_001156799.1) (Uniprot Accession #Q5ZKW9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428)
MBNL1 protein is a 343 amino acid peptide with an estimated molecular weight of 36.5kD. It binds to CUG triplet repeat expansion dsRNA.
Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3\' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.
Immunogen: Recombinant human MBNL1 protein (1-343), with a GST tag. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MBNL1 are readily searchable from our website. Different antibodies against the same target such as MBNL1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Embryonic Tissue, Head, Heart, Limb, Liver, Muscle, Other, Spleen tissues are correlated with this protein. Adenocarcinoma, Brain Diseases, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Neoplasms, Nervous System Diseases, Thrombosis, Weight Gain, Weight Loss are some of the diseases may be linked to Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428).