|The Map2k4 map2k4 (Catalog #MBS615479) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SEK1, phosphorylated (Ser80) (MKK4, SAPK, Erk Kinase, MKK4, Jun Kinase Kinase, JNKK) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SEK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).
Suitable for use in Western Blotting, Immunoprecipitation.
Dilution: Western Blot: 1:1000
Immunoprecipitation 1:25. Researchers should empirically determine the suitability of the Map2k4 map2k4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Map2k4 map2k4 product has the following accession number(s) (GI #1754531) (Uniprot Accession #P47809). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines (1-3). Activation of SEK1 occurs through phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at serine 80 inhibits SEK1 and suppresses the stress-activated signal transduction (5).
Immunogen: Synthetic phosphopeptide (KLH coupled) corresponding to residues surrounding Ser80 of human SEK1/MKK4. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Map2k4 are readily searchable from our website. Different antibodies against the same target such as Map2k4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Map2k4 also interacts with the following gene(s): Map3k1. Bone, Bone Marrow, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Skin, Thymus tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Female Urogenital Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Skin Diseases, Urogenital Neoplasms are some of the diseases may be linked to SEK1, phosphorylated (Ser80) (MKK4, SAPK, Erk Kinase, MKK4, Jun Kinase Kinase, JNKK).