anti-LMNB2 antibody product blog
Tags: Antibody; Polyclonal Antibody; Lamin B2; anti-LMNB2 antibody; LMNB2;
The LMNB2 lmnb2 (Catalog #MBS175503) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Lamin B2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Lamin B2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin. Researchers should empirically determine the suitability of the LMNB2 lmnb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The LMNB2 lmnb2 product has the following accession number(s) (GI #23503078) (NCBI Accession #Q03252.3) (Uniprot Accession #Q03252). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Lamin B2 antibody with the following immunoassay(s):
Western Blot (WB) (Anti-Lamin B2 antibody, MBS175503, Western blotting
Lane 1: HELA Cell Lysate
Lane 2: U87 Cell Lysate
)
Immunohistochemistry (IHC) (Anti-Lamin B2 antibody, MBS175503, IHC(P)
IHC(P): Rat Intestine Tissue
)
Description: Rabbit IgG polyclonal antibody for Lamin-B2(LMNB2) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.
Background: Lamin B2, also called LMNB2, is a protein associated with laminopathies. The LMNB2 gene is mapped to the G-negative subtelomeric band p13.3 of chromosome 19 by in situ hybridization. The LMNB2 gene contains 12 exons. Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2, is generated as part of the International Knockout Mouse Consortium program-a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. A highly sensitive procedure about mapping the start site of DNA replication in a 13.7-kb region of human chromosome 19 coding for lamin B2 is developed for the identification of the origin of bidirectional DNA synthesis in single-copy replicons of mammalian cells.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B2 (580-597aa EEDLFHQQGDPRTTSRGC), identical to the related rat and mouse sequences. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing LMNB2 are readily searchable from our website. Different antibodies against the same target such as LMNB2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.