anti-LMAN1 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-lman1 antibody; lman1;
The LMAN1 lman1 (Catalog #MBS835014) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s LMAN1 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB).IF: 1:100
WB: 1:200-500. Researchers should empirically determine the suitability of the LMAN1 lman1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The LMAN1 lman1 product has the following accession number(s) (GI #5031873) (NCBI Accession #NP_005561) (Uniprot Accession #P49257). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the LMAN1 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant LMAN1 protein (Right) or empty vector (Left) detected with LMAN1 antibody)
Mouse monoclonal LMAN1 antibody.
Biological Significance: LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in its gene are associated with a coagulation defect. Using positional cloning, its gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. Cross-Reactivity: Human, Monkey
Immunogen: LMAN1 antibody was raised in mouse using a full length recombinant protein of human LMAN1 (NP_005561) produced in HEK293T cells, as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing LMAN1 are readily searchable from our website. Different antibodies against the same target such as LMAN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Bone Marrow, Brain, Eye, Kidney, Liver, Muscle, Skin, Testis tissues are correlated with this protein. Abnormalities, Drug-Induced, Carcinoma, Hepatocellular, FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 1, Fibrosis, Hemorrhage, Inflammation, Liver Diseases, Liver Neoplasms, Poisoning, Prenatal Exposure Delayed Effects are some of the diseases may be linked to LMAN1 antibody. The following patways have been known to be associated with this gene.