anti-jak2b antibody product blog
Tags: Antibody; Polyclonal Antibody; JAK2; anti-jak2b antibody; jak2b;
The jak2b n/a (Catalog #MBS621761) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JAK2 (Janus Kinase 2) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s JAK2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the jak2b n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The jak2b n/a product has the following accession number(s) (GI #226237500) (NCBI Accession #BAH47262.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the JAK2 (Janus Kinase 2) with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MBS621761.)
The Janus (JAK) family of cytoplasmic tyrosine kinases has been implicated in signal transduction induced by cytokines and growth factors, physically associated with ligand-bound receptors. This association that results in tyrosine phosphorylation and activation. JAK1 is approximately 130kD and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among JAK family members. Family members such as JAK1, JAK2, and TYK2 are ubiquitous, whereas JAK3 is predominantly expressed in T lymphocytes. Studies with mutant cells that do not express JAK1, JAK2, or TYK2 show that their activation is essential for cellular signaling. JAK family kinases may either phosphorylate each other or be phosphorylated by a yet undescribed tyrosine kinase. Different cytokines can activate via phosphorylation distinct JAK family members. In some cells, the membrane-associated gp130 protein has been implicated in the induction of JAK family phosphorylation, although gp130 itself has no known activity.
Immunogen: Synthesized non-phosphopeptide derived from human Jak2 around the phosphorylation site of tyrosine 570 (G-D-YP-G-Q). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing jak2b are readily searchable from our website. Different antibodies against the same target such as jak2b may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.