anti-INS antibody product blog
Tags: Antibody; INS; Proinsulin; Monoclonal Antibody; anti-INS antibody;
The INS ins (Catalog #MBS530664) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Proinsulin antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Proinsulin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the INS ins for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The INS ins product has the following accession number(s) (GI #4557671) (NCBI Accession #NP_000198.1) (Uniprot Accession #P01308). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Mouse monoclonal Proinsulin antibody.
Biological Significance: Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene. Proinsulin is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where it is packaged into secretory vesicles, and where it is processed by a series of proteases to form mature insulin. Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen: Proinsulin antibody was raised in mouse using human proinsulin as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing INS are readily searchable from our website. Different antibodies against the same target such as INS may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. INS also interacts with the following gene(s): AKT1, FOXO1, IGF1R, IGFBP1, INSR, IRS1, IRS2, PDX1. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Muscle, Nerve, Pancreas, Vascular tissues are correlated with this protein. Diabetes Mellitus, Diabetes Mellitus, Type 2, Hyperglycemia, Hyperinsulinism, Hypertension, Hypoglycemia, Insulin Resistance, Metabolic Diseases, Obesity, Polycystic Ovary Syndrome are some of the diseases may be linked to Proinsulin antibody.