anti-HSPG2 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-Hspg2 antibody; Hspg2; Heparan-Sulfate Proteoglycan;
The HSPG2 hspg2 (Catalog #MBS608151) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Heparan-Sulfate Proteoglycan reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Heparan-Sulfate Proteoglycan can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).Suitable for use in ELISA, Western Blotting, Immunohistochemistry.
Dilution: ELISA: 1ug/ml
Western Blotting: 1ug/ml
Immunohistochemistry: 1ug/ml. Researchers should empirically determine the suitability of the HSPG2 hspg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HSPG2 hspg2 product has the following accession number(s) (GI #184427) (Uniprot Accession #P98160). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The principal molecular structure of basement membranes has been elucidated during the past two decades and it was shown that for example in the glomerular basement membrane (GBM) HS-PG are responsible for the selective filtration process. Removal of HS-PG will lead to proteinuria. Whereas previously perlecan was the only known basement membrane HS-PG, there is now evidence that (at least two) other basement membrane HS-PG do exist: Agrin, originally discovered as an important component of the neuromuscular junction and a novel small HS-PG, that was isolated from human aorta and kidney. This HS-PG, with a molecular weight of 80-200kD (aorta) and 30-160kD (kidney) and a core protein size of 24kD or 22kD, respectively, was localized by immunohisto-hemistry to the basement membrane. Amino acid sequence analysis of tryptic peptides indicate, that this small HS-PG is clearly distinct from perlecan and agrin.
Immunogen: Purified human small basement membrane heparan sulfate proteoglycan (HS-PG). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HSPG2 are readily searchable from our website. Different antibodies against the same target such as HSPG2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Alzheimer Disease, Bone Diseases, Developmental, Carcinoma, Congenital Abnormalities, Dyssegmental dysplasia, Kidney Diseases, Neoplasms, Neurodegenerative Diseases, Osteochondrodysplasias, SCHWARTZ-JAMPEL SYNDROME, TYPE 1 are some of the diseases may be linked to Heparan-Sulfate Proteoglycan. HSPG2 also interacts with the following gene(s): APP, FGF2, ITGB1, NID1. Blood, Bone, Brain, Connective Tissue, Embryonic Tissue, Eye, Kidney, Muscle, Nerve, Vascular tissues are correlated with this protein.