anti-HMMR antibody product blog
Tags: Antibody; HMMR; anti-HMMR antibody; Polyclonal Antibody; RHAMM;
The HMMR hmmr (Catalog #MBS151400) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RHAMM Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s RHAMM can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).RHAMM antibody can be used for detection of RHAMM by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 5 mug/mL. Researchers should empirically determine the suitability of the HMMR hmmr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HMMR hmmr product has the following accession number(s) (GI #217272802) (NCBI Accession #NP_036617) (Uniprot Accession #O75330). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the RHAMM Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of RHAMM in rat stomach tissue lysate with RHAMM antibody at 0.5 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of RHAMM in human stomach tissue with RHAMM antibody at 2.5 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of RHAMM in human stomach tissue with RHAM antibody at 20 μg/mL.)
RHAMM Antibody: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.
Conjugate: Unconjugated
Immunogen: RHAMM antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human RHAMM.
Buffer: RHAMM Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HMMR are readily searchable from our website. Different antibodies against the same target such as HMMR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.