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anti-HHV-8 antibody product blog

Posted on 2014-12-25 12:35:56 by mybiosource_staff
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Tags: Antibody; Mouse Monoclonal Antibody; HHV-8; anti-HHV-8 antibody;
The HHV-8 n/a (Catalog #MBS370079) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HHV-8 reacts with Human and may cross-react with other species as described in the data sheet.
Specimen Preparation:

Paraffin sections: The antibody can be used on formalin-fixed paraffin-embedded (FFPE) tissue sections. Ensure tissue undergoes appropriate fixation to ensure best results. Pre-treatment of tissues with heat-induced epitope retrieval (HIER) is recommended using ImmunoDNA Retriever with Citrate, ImmunoDNA Retriever with EDTA or ImmunoDNA Digestor.

Frozen sections and cell preparations: The antibody can be used for labeling acetone-fixed frozen sections and acetone-fixed cell preparations. Researchers should empirically determine the suitability of the HHV-8 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HHV-8 with the following immunoassay(s):
Immunohistochemistry (IHC) (Inset: IHC of HHV-8 on a FFPE Infected Pleura Tissue)
Immunohistochemistry (IHC) HHV-8.

Quality Control Procedure
Quality Control Procedure HHV-8.

Kaposi\'s Sarcoma-associated herpes virus is the eighth human herpes virus; its formal name according to the International Committee on Taxonomy of Viruses is HHV-8. This virus causes Kaposi\'s Sarcoma, a cancer commonly occurring in AIDS patients, as well as Primary Effusion Lymphoma and some types of Multicentric Castleman\'s Disease.

Latent nuclear antigen (LNA-1, LNA, LANA-1), also known as ORF73, is a 222- or 234 kDa protein that is consistently expressed in HHV-8 infected cells. Anti-HHV-8 labels the latent nuclear antigen protein vial immunohistochemistry.

Localization: Nuclear
Control: Kaposi\'s Sarcoma
Stability: 3 years
Intended Use: For Analyte Specific Reagent.
This antibody is intended for use in Immunohistochemical applications on formalin- fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
Immunogen: Purified HHV-8 virus.
Summary and Explanation: Kaposi’s Sarcoma-associated herpes virus is the eighth human herpes virus; its formal name according to the International Committee on Taxonomy of Viruses is HHV-8. Anti-HHV-8 labels the latent nuclear antigen protein via immunohistochemistry.
Presentation: Antibody Type: Concentrated
Dilution: 1:25 - 1: 100
Volume: 1.0mL. Reactivity Note: Paraffin, Frozen
Precaution: 1. For professional users only. Ensure results are interpreted by a medical professional.
2. This product contains sodium azide (NaN3), a toxic chemical which may react with plumbing to form highly explosive build-ups of metal azides. Upon disposal, flush with large volumes of water to prevent sodium azide build-up.
3. Ensure proper handling procedures are used with reagent. Always wear proper laboratory equipment such as laboratory coat and gloves when handling reagents.
4. Unused solution should be disposed of according to local and federal regulations.
5. Do not ingest reagent. If reagent ingested, contact a poison control center immediately.
6. For complete recommendations for handling biological specimens please refer to the CDC document, “Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories” (7). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HHV-8 are readily searchable from our website. Different antibodies against the same target such as HHV-8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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