anti-HER3 antibody product blog
Tags: Antibody; Monoclonal Antibody; HER3 / ERBB3; anti-HER3 antibody; HER3;
The HER3 erbb3 (Catalog #MBS245813) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone 3F12] (IgG2a,k) to Human HER3 / ERBB3 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HER3 / ERBB3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA).ELISA, IHC-P (5 ug/ml)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Researchers should empirically determine the suitability of the HER3 erbb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HER3 erbb3 product has the following accession number(s) (GI #54792100) (NCBI Accession #NP_001973.2) (Uniprot Accession #P21860). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Monoclonal [clone 3F12] (IgG2a,k) to Human HER3 / ERBB3 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-HER3 antibody IHC of human placenta, trophoblast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC) (Anti-HER3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
ELISA (EIA) (Detection limit for recombinant GST tagged ERBB3 is approximately 3 ng/ml as a capture antibody.)
ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity.
Target Species: Human
Immunogen Description: ERBB3 (AAH02706, 21 a.a. ~ 332 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen: HER3 / ERBB3 antibody was raised against eRBB3 (AAH02706, 21 a.a. ~ 332 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HER3 are readily searchable from our website. Different antibodies against the same target such as HER3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.