anti-HDAC11 antibody product blog
Tags: Antibody; Polyclonal Antibody; HDAC11; anti-HDAC11 antibody;
The HDAC11 hdac11 (Catalog #MBS627032) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HDAC11, CT (Histone Deacetylase 11, HD11) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s HDAC11 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the HDAC11 hdac11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HDAC11 hdac11 product has the following accession number(s) (GI #217272877) (NCBI Accession #NP_079103.2) (Uniprot Accession #Q96DB2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HDAC11, CT (Histone Deacetylase 11, HD11) with the following immunoassay(s):
Western Blot (WB) (The anti-HDAC11 Pab is used in Western blot to detect HDAC11 in mouse brain tissue lysate.)
Immunohistochemistry (IHC) (Purified rabbit anti-HDAC11 antibody (C-term) was used in immunohistochemistry on Breast Carcinoma.)
Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human testicle tumor tissue reacted with HDAC11 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Immunogen: Synthetic peptide selected from the C-terminal region of human HDAC11 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HDAC11 are readily searchable from our website. Different antibodies against the same target such as HDAC11 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.