anti-GRIA2/3 antibody product blog
Tags: Antibody; Polyclonal Antibody; GluR2/3; anti-GRIA2/3 antibody; GRIA2/3;
The GRIA2/3 gria2 (Catalog #MBS502065) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GluR2/3 reacts with Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s GluR2/3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Quality Control: Western blots performed on each lot.
WB: 1:1000. Researchers should empirically determine the suitability of the GRIA2/3 gria2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GRIA2/3 gria2 product has the following accession number(s) (GI #139394534) (NCBI Accession #NP_001077280.1) (Uniprot Accession #P19491). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-GluR2/3 with the following immunoassay(s):
Testing Data
Affinity purified rabbit polyclonal antibody.
Antigen: Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3.
Immunogen Information: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
Immunogen Species: Rat. Reactivity Assumed Based on 100% Sequence Homology: Chicken, human, mouse and zebra fish
Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with chicken, human, mouse and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Biological Significance: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Kein�nen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003;Seidenman et al., 2003;Chung et al., 2003;Yan et al., 2002). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GRIA2/3 are readily searchable from our website. Different antibodies against the same target such as GRIA2/3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.