|The GJB1 gjb1 (Catalog #MBS603226) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Connexin 32 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Connexin 32 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
Suitable for use in Immunofluorescence, Western Blotting, Immunohistochemistry.
Dilution: Immunofluorescence: 10ug/ml
Western Blotting: 1-3ug/ml
Immunohistochemistry: 10ug/ml. Researchers should empirically determine the suitability of the GJB1 gjb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GJB1 gjb1 product has the following accession number(s) (GI #974141) (Uniprot Accession #P08034). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Gap junctions are transmembrane channels that serve to directly link neighboring cells by mediating the exchange of lowmolecular weight metabolites, ions, and second messengers. Gap junctions are formed by the interaction of connexons or hemichannels on adjacent cells. The connexon itself is composed of a hexameric assembly of proteins referred to as connexins. Connexins are highly homologous proteins encoded by a multigene family. The connexins exhibit similar structural features which include a cytoplasmic amino terminal region, four transmembrane domains, two extracellular loops, and a carboxy-terminal cytoplasmic tail of varying length(1,2) Modulation of gap junction communication can be achieved by multiple mechanisms and can occur very rapidly or over a period of several hours. These mechanisms include alterations in transcription, translation, stability, posttranslational processing (especially phosphorylation), gating, and insertion or removal from the plasma membrane(3). Interestingly, reduction or alterations in the levels or types of connexin expressed in a given cell type has been found to correlate with tumor progression and metastasis(3,4).
Immunogen: Synthetic peptide derived from the C-terminus of mouse. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GJB1 are readily searchable from our website. Different antibodies against the same target such as GJB1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. GJB1 also interacts with the following gene(s): GJB2. Central Nervous System Diseases, Chromosome Aberrations, Congenital Abnormalities, Hearing Loss, Muscular Diseases, Nerve Degeneration, Nervous System Malformations, Neurodegenerative Diseases, Neurologic Manifestations, Pain are some of the diseases may be linked to Connexin 32.