anti-GHRL antibody product blog
Tags: Antibody; Acylation Stimulating Protein; Monoclonal Antibody; GHRL; anti-GHRL antibody;
The GHRL ghrl (Catalog #MBS600639) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Acylation Stimulating Protein (ASP) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Acylation Stimulating Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the GHRL ghrl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GHRL ghrl product has the following accession number(s) (GI #17865471) (NCBI Accession #Q9UBU3.1) (Uniprot Accession #Q9UBU3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Acylation Stimulating Protein (ASP, also known as C3a desArg) is one of the activation fragments formed from the activation of a complement cascade. ASP is produced through a process involving three proteins: C3, factor B and adipsin, which are secreted by adipocytes. Interactions of C3 with factor B and with adipsin result in the production of C3a followed by desargination of the carboxyl terminus to generate ASP (C3a desArg). Human ASP contains 77 amino acids with 6 cysteins involved in disulfide bridges between residues 22-49, 23-56 and 36-57. ASP is a highly cationic molecule containing no carbohydrate. ASP has a primary role in the regulation of lipid metabolism in adipocytes, where it stimulates glucose uptake, increases the activity of diacylglycerol acyltransferase, and inhibits hormone-sensitive lipase activity. In cellular studies, ASP increases fat storage through increased triglyceride synthesis and decreased intracellular lipolysis. In animal models, ASP-deficient mice demonstrate reduced body weight, reduced leptin and reduced adipose tissue mass. ASP deficiency also results in protection against development of obesity. In humans, a number of studies have shown the relationship between ASP, obesity, diabetes and dyslipidemia. It was reported that the concentration of circulating ASP is positively related to body adiposity and decreases after weight loss. Because ASP enhances triglyceride storage, while interfering with ASP production reduces body fat and protects against diet-induced obesity and insulin resistance, reduction of the production of ASP and ASP receptor antagonists represents a potential approach for treating obesity and type 2 diabetes.
Immunogen: Human peptide with amino acid sequence RASHLGLA (which is located in C-terminal part of the human ASP). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GHRL are readily searchable from our website. Different antibodies against the same target such as GHRL may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.