anti-FLT4 antibody product blog
Tags: Antibody; Polyclonal Antibody; FLT4; VEGFR3; anti-FLT4 antibody;
The FLT4 flt4 (Catalog #MBS625970) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s VEGFR3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC).ELISA: 1:10,000-1:100,000; 50-100ng of control peptide/well
Immunohistochemistry: 2-20ug/ml in formaldehyde fixed tissues. Researchers should empirically determine the suitability of the FLT4 flt4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FLT4 flt4 product has the following accession number(s) (GI #104294888) (NCBI Accession #NP_891555.2) (Uniprot Accession #P35916). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. This process is known as angiogenesis (sprouting of new capillary vessels from pre-existing vasculature). Study of tumor angiogenesis has led to the identification of several proteins including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor. VEGF acts by interacting with a family of largely endothelial-specific receptor tyrosine kinases that includes VEGFR1 (flt-1/flk-2), VEGFR2 (flk- 1/KDR), and VEGFR3/Flt-4. Disruption of VEGFRs interferes with differentiation of endothelial cells and it is lethal for the embryo. VEGFR3 (mouse 1363aa and human 1298aa), a receptor protein tyrosine kinase, is a receptor for VEGF-C. Mouse VEGFR3 protein topology: 1-24aa signal peptide, 25-1363 mature protein (25-775 EC domain, 776-797aa TM domain, 798-1363aa CP domain). VEGFR3 is type 1 membrane protein. It is expressed in adult lung, and liver, and in fetal liver, brain, intestine, and placenta.
Immunogen: Synthetic peptide corresponding to 20aa near the C-terminal,cytoplasmic domain of mouse VEGFR3, conjugated to KLH.Species Sequence Homology: rat; 85%, human; 73%. Control Peptide: F4601-03: Flt4, Mouse, Control Peptide (Fms-like Tyrosine Kinase 4)
Grade: Affinity Purified. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FLT4 are readily searchable from our website. Different antibodies against the same target such as FLT4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.