anti-EDA2R antibody product blog
Tags: Antibody; Polyclonal Antibody; XEDAR; anti-EDA2R antibody; EDA2R;
The EDA2R eda2r (Catalog #MBS151283) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XEDAR Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s XEDAR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).XEDAR antibody can be used for the detection of XEDAR by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. Researchers should empirically determine the suitability of the EDA2R eda2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EDA2R eda2r product has the following accession number(s) (GI #37222208) (NCBI Accession #AAQ89953) (Uniprot Accession #Q9HAV5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the XEDAR Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of XEDAR in 293 cell lysate with XEDAR antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of XEDAR in human skin tissue with XEDAR antibody at 10 μg/mL.)
XEDAR Antibody: X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-κB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
Conjugate: Unconjugated
Immunogen: XEDAR antibody was raised against recombinant human XEDAR.
Buffer: XEDAR Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EDA2R are readily searchable from our website. Different antibodies against the same target such as EDA2R may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.