anti-DOG1 antibody product blog
Tags: Antibody; Monoclonal Antibody; DOG1; anti-DOG1 antibody;
The DOG1 n/a (Catalog #MBS370152) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DOG1 RMab reacts with Human and may cross-react with other species as described in the data sheet.The DOG1 n/a product has the following accession number(s) (GI #323099808). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the DOG1 RMab with the following immunoassay(s):
Dilution Information
Immunohistochemistry (IHC)
DOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody. DOG1 identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST identification.
Control: GIST
Localization: Cytoplasmic, Membranous. Reactivity Note: Paraffin, Frozen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DOG1 are readily searchable from our website. Different antibodies against the same target such as DOG1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. DOG1 also interacts with the following gene(s): FLNA. Bone, Brain, Connective Tissue, Ear, Embryonic Tissue, Heart, Kidney, Muscle, Umbilical Cord, Vascular tissues are correlated with this protein.