anti-DLL3 antibody product blog
Tags: Antibody; Monoclonal Antibody; DLL3; anti-DLL3 antibody;
The DLL3 dll3 (Catalog #MBS601745) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s DLL3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Western Blot: 1ug/ml using recombinant human DLL3
Optimal dilutions to be determined by the researcher.
Other applications not tested. Researchers should empirically determine the suitability of the DLL3 dll3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DLL3 dll3 product has the following accession number(s) (GI #45243561) (NCBI Accession #NP_982353.1) (Uniprot Accession #Q9NYJ7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Delta-like 3 (DLL3) is a transmembrane Delta-like protein that contains one DSL domain and six EGF-like repeats. DLL3 is critical for somite segmentation and neurogenesis during early embryonic development. It does not bind Notch receptors but functions as an antagonist of Notch signaling. Defects in DLL3 cause axial skeletal abnormalities in spondylocostal dysostosis. Within the extracellular domain, human DLL3 shares 84% amino acid sequence identity with mouse and rat DLL3.
Immunogen: Recombinant protein corresponding to Ala27-Pro488 from human DLL3 expressed in CHO cells.
Grade: Affinity Purified. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DLL3 are readily searchable from our website. Different antibodies against the same target such as DLL3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. DLL3 also interacts with the following gene(s): DLL1, HES5, HES7, JAG1, LFNG, MESP2, NOTCH1, NOTCH3, RBPJ. Brain, Embryonic Tissue, Eye, Lung, Pancreas, Pituitary Gland, Skin tissues are correlated with this protein. Astrocytoma, Carcinoma, Congenital Abnormalities, Craniofacial Abnormalities, Heart Diseases, Liver Diseases, Liver Neoplasms, Osteochondrodysplasias, SPONDYLOCOSTAL DYSOSTOSIS 1, AUTOSOMAL RECESSIVE, Scoliosis are some of the diseases may be linked to DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3).