Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Blog  rightarrow anti-DLL3 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • SLFNL1 shrna blog
 • ADAMTSL2 shrna blog
 • ARPC3 shrna blog
 • CLEC16A peptide blog
 • insulin autoantibodies, IAA elisa kit blog
 • NUTM2G shrna blog
 • anti-MMP8 antibody blog
 • IFNA2 recombinant protein blog
 • b-Casomorphin [Val3] [1-4] amide peptide blog
 • CRF peptide blog
 • MASTL sirna blog
 • CLPP sirna blog
 • anti-DNP antibody blog
 • N blocking peptide blog
 • PRMT1 sirna blog
 • Human IgG2 lambda G2m (n+) peptide blog
 • anti-PRDX1 antibody blog
 • SLC6A18 shrna blog
 • RPL26 blocking peptide blog
 • Tissue, Membrane Protein Adult Normal, Thyroid tissue lysate blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • Tetrahydrobiopterin (BH4) ELISA Kit
 • Fibulin 1 (FBLN1) Recombinant Protein
 • Low Density Lipoprotein (LDL) ELISA Kit
 • Angiopoietin-related protein 2 (ANGPTL2) Antibody
 • RBL2 - RB2 p130 Antibody
 • ATM Antibody
 • C-peptide Antibody
 • 5-oxoprolinase (OPLAH) Recombinant Protein
 • Major sperm protein 19-31-40-45-50-51-53-59-61- 65-81-113-142... Recombinant Protein
 • Troponin I Antibody
 • Interleukin 17A (IL-17A) ELISA Kit
 • C1 inhibitor (SERPING1) Antibody
 • IL12 Antibody
 • SLC27A6 Antibody
 downarrow more ...
separator

anti-DLL3 antibody product blog

separator
Posted on 2014-01-22 00:21:54 by mybiosource_staff
Share it on ...     
separator
separator
Tags: Antibody; Polyclonal Antibody; DLL3; anti-DLL3 antibody; DELTA-LIKE PROTEIN 3;
separator
The DLL3 dll3 (Catalog #MBS224287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3 reacts with Human (Weak) and may cross-react with other species as described in the data sheet. MyBioSource\'s DELTA-LIKE PROTEIN 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Western Blot: This item detects a prominent band of approximately 60-62kDa in mouse brain tissue, and weakly in human brain tissue.
Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/500. Researchers should empirically determine the suitability of the DLL3 dll3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The DLL3 dll3 product has the following accession number(s) (GI #8393264) (NCBI Accession #NP_058637.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3 with the following immunoassay(s):
Testing Data #1 (Mouse brain lysate probed with Rabbit anti Mouse Delta-Like Protein 3 (MBS224287) followed by Sheep anti Rabbit IgG:HRP (MBS235194))
Testing Data #1 DLL3.

This antibody recognises mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation defects.

horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions