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anti-DLL3 antibody product blog

Posted on 2014-01-22 00:21:54 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; DLL3; anti-DLL3 antibody; DELTA-LIKE PROTEIN 3;
The DLL3 dll3 (Catalog #MBS224287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3 reacts with Human (Weak) and may cross-react with other species as described in the data sheet. MyBioSource\'s DELTA-LIKE PROTEIN 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Western Blot: This item detects a prominent band of approximately 60-62kDa in mouse brain tissue, and weakly in human brain tissue.
Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/500. Researchers should empirically determine the suitability of the DLL3 dll3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The DLL3 dll3 product has the following accession number(s) (GI #8393264) (NCBI Accession #NP_058637.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3 with the following immunoassay(s):
Testing Data #1 (Mouse brain lysate probed with Rabbit anti Mouse Delta-Like Protein 3 (MBS224287) followed by Sheep anti Rabbit IgG:HRP (MBS235194))
Testing Data #1 DLL3.

This antibody recognises mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation defects.

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