|The DLG4 dlg4 (Catalog #MBS608337) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, (Drosophila) Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90) reacts with Bovine, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Postsynaptic Density Protein 95 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF).
Suitable for use in Western Blot, Immunofluorescence, Immunocytochemistry and Immunohistochemistry.
Dilution: Western Blot: 1:250. Detects an ~100kD band corresponding to the apparent molecular mass of PSD-95 on SDS-PAGE blots. An additional band of > 100kD is also detected. Additional crossreactive bands are detected at ~75kD and 50kD in rat and mouse samples. Researchers should empirically determine the suitability of the DLG4 dlg4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DLG4 dlg4 product has the following accession number(s) (GI #3318653) (NCBI Accession #AAC52113.1) (Uniprot Accession #P78352). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Postsynaptic Density Protein 95 (PSD-95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3,4). PSD-95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD-95 are associated with autism (7).
Immunogen: Recombinant rat Postsynaptic Density Protein 95. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DLG4 are readily searchable from our website. Different antibodies against the same target such as DLG4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.