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anti-CYP2D6 antibody product blog

Posted on 2014-06-17 09:35:23 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; Cytochrome P450 2D6; CYP2D6; anti-CYP2D6 antibody;
The CYP2D6 cyp2d6 (Catalog #MBS175727) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Cytochrome P450 2D6 antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Cytochrome P450 2D6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the CYP2D6 cyp2d6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The CYP2D6 cyp2d6 product has the following accession number(s) (GI #84028191) (NCBI Accession #P10635.2) (Uniprot Accession #P10635). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Cytochrome P450 2D6 antibody with the following immunoassay(s):
Western Blot (WB) (Anti-Cytochrome P450 2D6 antibody, MBS175727, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Kidney Tissue Lysate
Lane 3: Rat Brain Tissue Lysate
Western Blot (WB) CYP2D6.

Description: Rabbit IgG polyclonal antibody for Cytochrome P450 2D6(CYP2D6) detection. Tested with WB, IHC-P in Mouse, Rat.
Background: Cytochrome P450 2D6(CYP2D6) is one of the most important enzymes involved in the metabolism of xenobiotics in the body. It is a member of Cytochrome P450, family 2, subfamily D, polypeptide 6. Its gene is mapped to chromosome 22q13.1. It has got 497 amino acid proteins which shares 73% sequence identity with the rat protein. CYP2D6 is highly expressed in human liver. CYP2D6 is the major isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus syndrome observed with procainamide.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse Cytochrome P450 2D6 (194-214aa FACRFEYNDPRFIRLLDLLKD), identical to the related rat sequence. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CYP2D6 are readily searchable from our website. Different antibodies against the same target such as CYP2D6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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