anti-COL4A2 antibody product blog
Tags: Antibody; Polyclonal Antibody; Collagen IV; anti-COL4A2 antibody; COL4A2;
The COL4A2 col4a2 (Catalog #MBS175589) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Collagen IV antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Collagen IV can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC. Researchers should empirically determine the suitability of the COL4A2 col4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The COL4A2 col4a2 product has the following accession number(s) (GI #143811377) (NCBI Accession #P08572.4) (Uniprot Accession #P08572). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Collagen IV antibody with the following immunoassay(s):
Western Blot (WB) (Anti-Collagen IV antibody, MBS175589, Western blotting
Lane 1: Rat Kidney Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
)
Immunohistochemistry (IHC) (Anti-Collagen IV antibody, MBS175589, IHC(F)
IHC(F): Rat Kidney Tissue )
Immunohistochemistry (IHC) (Anti-Collagen IV antibody, MBS175589, IHC(P)
IHC(P): Mouse Lung Tissue )
Description: Rabbit IgG polyclonal antibody for Collagen alpha-2(IV) chain(COL4A2) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.
Background: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen IV (1697-1712aa LIRTHISRCQVCMKNL), identical to the related rat and mouse sequences. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing COL4A2 are readily searchable from our website. Different antibodies against the same target such as COL4A2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. COL4A2 also interacts with the following gene(s): COL15A1, COL1A1, COL1A2, COL3A1, COL4A1, COL4A5, COL5A2, COL6A2, COL6A3.