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anti-CLDN16 antibody product blog

Posted on 2013-10-29 08:35:15 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; Claudin 16; anti-CLDN16 antibody; CLDN16;
The CLDN16 cldn16 (Catalog #MBS630235) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Claudin 16 (Paracellin 1, CLDN16) reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Claudin 16 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF).
Dilution: Immuno uorescence: 1-3ug/ml
Immunohistochemistry (Frozen): 10ug/ml. Researchers should empirically determine the suitability of the CLDN16 cldn16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The CLDN16 cldn16 product has the following accession number(s) (GI #5729970) (NCBI Accession #NP_006571.1) (Uniprot Accession #Q9Y5I7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle\'s loop (TAL), the distal tubule, and the collecting duct(6). Antibodies against Tamm-Horsfall protein (THP) (a TAL marker) are used to localize this specific structure of nephrons in kidney sections(1). Mg2+ resorption occurs in TAL(2), and Claudin 16 is required for this paracellular function(3). Failure in renal \'handling\' of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems(5). Tight junctions are specialized regions of cell-cell contact that are particularly abundant in luminal epithelial cell sheets. In freeze-fracture electron micrographs, tight junctions are visualized as belt-like bands of anastomosing sealing strands (TJ strands) that completely encircle the lateral surfaces of each cell. TJ strands on adjacent cells are presumed to interact with each other to form a sort of "molecular gasket" that prevents ions, water and other molecules from leaking between cells and thus, from one side of the sheet to the other. In addition to this so-called "barrier" function, the "fence" function of tight junctions plays an important role in maintaining epithelial cell-polarity by blocking the diffusion of membrane proteins between apical (luminal) and basolateral cell surfaces. Claudin proteins have been shown to be major integral membrane proteins localized at tight junctions.

CLDN16 cldn16

Immunogen: Synthetic peptide corresponding to the C-terminal region of human Claudin 16. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CLDN16 are readily searchable from our website. Different antibodies against the same target such as CLDN16 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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