|The chx 10 vsx2 (Catalog #MBS395910) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The chx 10 (NT) reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s chx 10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Frozen. Researchers should empirically determine the suitability of the chx 10 vsx2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The chx 10 vsx2 product has the following accession number(s) (GI #34365783) (NCBI Accession #NP_878314.1) (Uniprot Accession #P58304). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the chx 10 (NT) with the following immunoassay(s):
Western Blot/Blotting (Western blot analysis using anti-Chx10 (NT))
Chx10 is a 46kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.
Immunogen: Antibody raised against a recombinant protein corresponding to amino acids 1 to 131 derived from the N terminal of the human Chx10 protein conjugated to GST. Positive Control: Rat or mouse retinal tissue lysate. Suitable for use against recombinant proteins conjugated to OVA, GST, His tags and other. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing chx 10 are readily searchable from our website. Different antibodies against the same target such as chx 10 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. chx 10 also interacts with the following gene(s): ATOH7, CDKN1B, MFRP, NES, NXNL1, PAX6, POU4F2, SIX3. Brain, Eye, Muscle tissues are correlated with this protein. Disease Models, Animal, Microphthalmia, Isolated 2, Neoplasms, Premature Birth, Uterine Diseases, Weight Loss are some of the diseases may be linked to chx 10 (NT).