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anti-CDH2 antibody product blog

Posted on 2013-10-18 19:40:39 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; anti-CDH2 antibody; CDH2; N-Cadherin (Cytoplasmic);
The CDH2 cdh2 (Catalog #MBS470018) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The N-Cadherin (Cytoplasmic) reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s N-Cadherin (Cytoplasmic) can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation.
ELISA: 1:2000
Immunocytochemistry: 1:200
Immunoprecipitation: 1:100
Western Blot: 1:1000. Researchers should empirically determine the suitability of the CDH2 cdh2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The CDH2 cdh2 product has the following accession number(s) (GI #253483) (Uniprot Accession #P19022). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the N-Cadherin (Cytoplasmic) with the following immunoassay(s):
Testing Data
Testing Data CDH2.

Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. This region induces clustering and also binds to the protein p120 catenin. The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton. Many cadherins are regulated by phosphorylation, including N-cadherin and E-cadherin. N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr -886. Phosphorylation of Tyr-860 can disrupt cadherin binding to bcatenin. Since many of these tyrosine sites are conserved in the cadherin family, phosphorylation of these sites may be critical for cadherin function.

Immunogen: Clone (M170) was generated from a human recombinant N-Cadherin protein containing amino acids in the C-terminal region. This sequence is highly conserved in rat and mouse N-Cadherin, and has some homology to R-cadherin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CDH2 are readily searchable from our website. Different antibodies against the same target such as CDH2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Carcinoma, Cardiovascular Diseases, Endocrine Gland Neoplasms, Female Urogenital Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neuroectodermal Tumors, Skin Diseases are some of the diseases may be linked to N-Cadherin (Cytoplasmic).
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