anti-CD8 antibody product blog
Tags: Antibody; CD8; Monoclonal Antibody; anti-CD8 antibody;
The CD8 n/a (Catalog #MBS140049) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Introduction: CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains binds to class-I MHC molecules alpha-3 domains.
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen: Purified human PBL CD8+ T cells.
Antibody Properties: Blocking and staining antibody. For staining, use 10 ul/1,000,000 cells. Titer for blocking T cell activation should be determined by the investigator.
Available Conjugates: This antibody is also available conjugated to biotin and FITC. For staining with biotin or FITC-conjugated antibody use 5-10 ul/106 cells. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD8 are readily searchable from our website. Different antibodies against the same target such as CD8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.