|The CD1A cd1a (Catalog #MBS140096) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase.
The CD1A cd1a product has the following accession number(s) (GI #110618224) (NCBI Accession #NP_001754.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Introduction: CD1a is a transmembrane glycoproteins, which is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. CD1a mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen: Purified human PBL T cells.
Antibody Properties: Staining antibody. For staining, use 10 ul/1,000,000 cells. This antibody recognizes human thymocytes. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD1A are readily searchable from our website. Different antibodies against the same target such as CD1A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. CD1A also interacts with the following gene(s): B2M, CD1B, CD1E, CD207, CD9, IL1B. Breast Neoplasms, Cardiovascular Diseases, Death, Fibrosis, Hyperplasia, Inflammation, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis are some of the diseases may be linked to Mouse Anti Human CD1A (T6, LEU6). Blood, Brain, Heart, Lung, Lymph Node, Skin, Thymus tissues are correlated with this protein.