anti-CD105 antibody product blog
Tags: Antibody; Polyclonal Antibody; CD105; anti-CD105 antibody;
The CD105 eng (Catalog #MBS857479) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The CD105 (Endoglin) Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s CD105 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).WB: 1:500. Researchers should empirically determine the suitability of the CD105 eng for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD105 eng product has the following accession number(s) (GI #226437647) (NCBI Accession #NP_031958.2) (Uniprot Accession #Q63961). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CD105 (Endoglin) Antibody with the following immunoassay(s):
Western Blot (Western blot analysis on D3 using anti CD105 polyclonal antibody.)
Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver.
Preservative: 0.05% Sodium Azide.
Cellular Localization: Cell Membrane. Positive Control: D3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD105 are readily searchable from our website. Different antibodies against the same target such as CD105 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Bone, Bone Marrow, Brain, Connective Tissue, Eye, Heart, Liver, Lung, Muscle, Skin tissues are correlated with this protein. Atherosclerosis, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Hypertension, Inflammation, Liver Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to CD105 (Endoglin) Antibody.