anti-CD105 antibody product blog
Tags: Antibody; Monoclonal Antibody; CD105; anti-CD105 antibody;
The CD105 eng (Catalog #MBS850485) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD105 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD105 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA).WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
FC: 1:200-1:400
ELISA: 1:10000. Researchers should empirically determine the suitability of the CD105 eng for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD105 eng product has the following accession number(s) (GI #4557555) (NCBI Accession #NP_000109.1) (Uniprot Accession #P17813). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CD105 Antibody with the following immunoassay(s):
Western Blot (WB) (Figure 1: Western blot analysis using CD105 mAb against HEK293 (1) and CD105-hIgGFc transfected HEK293 (2) cell lysate.)
Immunohistochemistry (IHC) (Figure 2: Immunohistochemical analysis of paraffin-embedded kidney cancer tissues (left) and stomach cancer tissues (right) using CD105 mouse mAb with DAB staining.)
Testing Data
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
Immunogen: Purified recombinant fragment of human CD105 expressed in E. Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD105 are readily searchable from our website. Different antibodies against the same target such as CD105 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CD105 also interacts with the following gene(s): ACVRL1, BMP2, GIPC1, HIF1A, SMAD4, TGFB1, TGFBI, TGFBR1, TGFBR2. Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Drug Toxicity, Heart Diseases, Hypertension, Inflammation, Liver Diseases, Neoplasms, Nervous System Diseases are some of the diseases may be linked to CD105 Antibody. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Connective Tissue, Eye, Heart, Muscle, Nerve, Skin, Vascular tissues are correlated with this protein.