anti-CCR5 antibody product blog
Tags: Antibody; anti-CCR5 antibody; CCR5; Monoclonal Antibody;
The CCR5 ccr5 (Catalog #MBS246596) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone T21/8] (IgG1,k) to Human CCR5 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CCR5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), ELISA (EIA).ELISA, Flo, IHC-P (20 ug/ml), IP, WB
Usage: This T21/8 (T21/8) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample.. Researchers should empirically determine the suitability of the CCR5 ccr5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CCR5 ccr5 product has the following accession number(s) (GI #4502639) (NCBI Accession #NP_000570.1) (Uniprot Accession #P51681). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Monoclonal [clone T21/8] (IgG1,k) to Human CCR5 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-CCR5 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)
Flow Cytometry (FC/FACS) (Staining of normal human peripheral blood cells with 0.25 ug of Purified Mouse IgG1, K isotype control (open histogram) or 0.25 ug of Purified anti-human CCR5 (T21/8) (colored histogram) followed by Biotin Anti-Mouse IgG and SAv-PE. Cells in the lymphocyte gate were used for analysis.)
CCR5, a Chemokine Receptor, is a coreceptor for the human immunodeficiency virus-1 (HIV-1). HIV progression and resistance has been linked to variable CCR5 transcripts. For example, the disease progression from HIV-1 infection to AIDS appears to be slower in patients heterozygous for a 32-bp CCR5 deletion than in individuals homozygous for the normal CCR5 allele. The CCR5 gene is located near the genes for CCR2 and chemokine (C-C motif) receptor-like 2 on chromosome 3.
Target Species: Human
Immunogen Description: Human CCR5. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CCR5 are readily searchable from our website. Different antibodies against the same target such as CCR5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.