|The BIRC5 birc5 (Catalog #MBS175675) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-survivin antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s survivin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the BIRC5 birc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The BIRC5 birc5 product has the following accession number(s) (GI #380865472) (NCBI Accession #O15392.3) (Uniprot Accession #O15392). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-survivin antibody with the following immunoassay(s):
Western Blot (WB) (Anti-survivin antibody, MBS175675, Western blotting
Lane 1: HELA Cell Lysate
Lane 2: JURKAT Cell Lysate
Lane 3: CEM Cell Lysate
Lane 4: COLO320 Cell Lysate
Description: Rabbit IgG polyclonal antibody for Baculoviral IAP repeat-containing protein 5(BIRC5) detection. Tested with WB in Human.
Background: Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis(IAP) family. The survivin gene contains 4 exons. The survivin gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human survivin (121-142aa KKEFEETAKKVRRAIEQLAAMD). Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing BIRC5 are readily searchable from our website. Different antibodies against the same target such as BIRC5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. BIRC5 also interacts with the following gene(s): AURKA, AURKB, CDC20, CDCA8, CDK1, FOXM1, INCENP, PLK1, SGOL2, XIAP.