|The BCL10 bcl10 (Catalog #MBS150410) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bcl-10 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Bcl-10 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF).
Bcl-10 antibody can be used for detection of BCL10 by Western blot at 0.5 mug/mL. dilution. An approximately 31 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 1 mug/mL. For immunofluorescence start at 10 mug/mL. Researchers should empirically determine the suitability of the BCL10 bcl10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The BCL10 bcl10 product has the following accession number(s) (GI #5070371) (NCBI Accession #AF134395) (Uniprot Accession #O95999). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Bcl-10 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.)
Immunocytochemistry (ICC) (Immunocytochemistry of Bcl10 in Raji cells with Bcl10 antibody at 1 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of Bcl-10 in Raji cells with Bcl-10 antibody at 10 μg/mL.)
Bcl-10 Antibody: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.
Immunogen: Bcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10.
Buffer: Bcl-10 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing BCL10 are readily searchable from our website. Different antibodies against the same target such as BCL10 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.