|The BCCIP bccip (Catalog #MBS120475) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse monoclonal antibody Anti-Human BCCIP reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s BCCIP can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB). Researchers should empirically determine the suitability of the BCCIP bccip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The BCCIP bccip product has the following accession number(s) (GI #169790844) (NCBI Accession #NP_057651.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse monoclonal antibody Anti-Human BCCIP with the following immunoassay(s):
Quality Control (Western blot analysis of immunized recombinant protein, using anti-BCCIP monoclonal antibody.)
Quality Control #2 (Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.)
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The Nterminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq][NCBI Entrez Gene Summary].
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Sterility: Filtered through a 0.22 um membrane. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing BCCIP are readily searchable from our website. Different antibodies against the same target such as BCCIP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Carcinoma, Hepatocellular, Chromosome Aberrations, Intestinal Neoplasms, Kidney Diseases, Skin Neoplasms, Uterine Cervical Neoplasms are some of the diseases may be linked to Mouse monoclonal antibody Anti-Human BCCIP.