|The b-Dystroglycan (Tyr-892) n/a (Catalog #MBS470003) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The beta-Dystroglycan (Tyr-892), phospho-specific reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s b-Dystroglycan (Tyr-892) can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot.
Western Blot: 1:1000. Researchers should empirically determine the suitability of the b-Dystroglycan (Tyr-892) n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the beta-Dystroglycan (Tyr-892), phospho-specific with the following immunoassay(s):
Dystroglycans are essential elements of the neuromuscular junction (NMJ). The gene for dystroglycan is expressed as a precursor protein that is post-translationally cleaved into a 156 kDa extracellular peripheral membrane protein called a-dystroglycan and a 43 kDa transmembrane protein, b-dystroglycan. The latter protein contains a PPxY motif that promotes binding to WW domain-containing proteins, such as utrophin and dystrophin. Phosphorylation at tyrosine 892 within the PPxY motif may regulate c-Src interactions with beta-dystroglycan, as well as inhibit interactions with WW domain proteins. In skeletal muscle, beta-dystroglycan is normally localized to the plasma membrane, however phosphorylation of Tyr-892 leads to localization of beta-dystroglycan to endosomal compartments along with c-Src. Thus, phosphorylation at Tyr-892 may have important roles in altering the localization of beta-dystroglycan during NMJ formation.
Immunogen: Clone (M117) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 892 of human
dystroglycan. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse dystroglycan. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing b-Dystroglycan (Tyr-892) are readily searchable from our website. Different antibodies against the same target such as b-Dystroglycan (Tyr-892) may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.