anti-b-Amyloid 1-40, 42 antibody product blog
Tags: Antibody; Monoclonal Antibody; b-Amyloid 1-40, 42; anti-b-Amyloid 1-40, 42 antibody;
The b-Amyloid 1-40, 42 n/a (Catalog #MBS601661) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The b-Amyloid 1-40, 42 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s b-Amyloid 1-40, 42 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Western Blot: 1:1000-1:5000 (ECL). Researchers should empirically determine the suitability of the b-Amyloid 1-40, 42 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Alzheimer\'s Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1-40, 1-42 and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140aa a-synucleins is identical with non- Ab component (NACP) of AD. The 134aa human b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine may cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms: two large (140 aa SYN-1 & 149 aa SYN-2) and a small form (SYN-3, 42 aa) are produced by alternative splicing.
Immunogen: Human beta Amyloid 1-40 (KLH). Epitope: Localized to the N-terminus of beta amyloid (1-13 aa of 1-40/42/43). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing b-Amyloid 1-40, 42 are readily searchable from our website. Different antibodies against the same target such as b-Amyloid 1-40, 42 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.