anti-ATF2 antibody product blog
Tags: Antibody; Monoclonal Antibody; ATF2; anti-ATF2 antibody; Activating Transcription Factor 2;
The ATF2 n/a (Catalog #MBS632848) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Activating Transcription Factor 2, phosphorylated (Thr71) (ATF2, cAMP Response Element Binding Protein 2, CRE BP1, CREB 2, CREB2, CREBP1, HB 16, HB16, MGC111558, mXBP, TREB 7, TREB7) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Activating Transcription Factor 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot.
Dilution: Western Blot: 2ug/ml. Researchers should empirically determine the suitability of the ATF2 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ATF2 n/a product has the following accession number(s) (GI #274322606) (NCBI Accession #NP_001075053.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites (1-3). Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
Immunogen: Synthetic peptide containing phosphorylated threonine at position 71 of human ATF-2. Positive Control: TNF-a treated HeLa (1 hr). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ATF2 are readily searchable from our website. Different antibodies against the same target such as ATF2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Connective Tissue, Ear, Embryonic Tissue, Heart, Kidney, Muscle, Umbilical Cord, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.