anti-APOA5 antibody product blog
Tags: Antibody; Monoclonal Antibody; ApoA5; anti-APOA5 antibody;
The APOA5 apoa5 (Catalog #MBS603509) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The APOA5 (Apolipoprotein A5, Apo A-V, Apolipoprotein A-V, ApoA-V) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s APOA5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).Suitable for use in ELISA. Researchers should empirically determine the suitability of the APOA5 apoa5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The APOA5 apoa5 product has the following accession number(s) (GI #262231737) (NCBI Accession #NP_001160070.1) (Uniprot Accession #Q6Q788). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
Immunogen: Ni-NTA purified full length recombinant human APOA5 expressed in E. Coli strain BL21 (DE3). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing APOA5 are readily searchable from our website. Different antibodies against the same target such as APOA5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Arteriosclerosis, Central Nervous System Diseases, Diabetes Mellitus, Type 2, Dyslipidemias, Hypertriglyceridemia, Insulin Resistance, Metabolic Syndrome X, Myocardial Infarction, Myocardial Ischemia, Obesity are some of the diseases may be linked to APOA5 (Apolipoprotein A5, Apo A-V, Apolipoprotein A-V, ApoA-V). Liver, Lung tissues are correlated with this protein.