|The ANAPC2 anapc2 (Catalog #MBS532814) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ANAPC2 antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ANAPC2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Western Blot (WB).
WB: 1:2000. Researchers should empirically determine the suitability of the ANAPC2 anapc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ANAPC2 anapc2 product has the following accession number(s) (GI #7019327) (NCBI Accession #NP_037498) (Uniprot Accession #Q9UJX6). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ANAPC2 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ANAPC2 protein (Right) or empty vector (Left) detected with ANAPC2 antibody)
Mouse monoclonal ANAPC2 antibody.
Biological Significance: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphasetransition by ubiquitin ating its specific substrates such as mitotic cyclins and anaphase inhibitor, which aresubsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eightsubunits. The composition of the APC is highly conserved in organisms from yeast to humans. ANAPC2 is a component of the complex and shares sequence similarity with a recently identified family of proteins calledcullins, which may also be involved in ubiquitin-mediated degradation. Immunogen: ANAPC2 antibody was raised in mouse using a full length recombinant protein of human ANAPC2 (NP_037498) produced in HEK293T cells, as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ANAPC2 are readily searchable from our website. Different antibodies against the same target such as ANAPC2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. ANAPC2 also interacts with the following gene(s): ANAPC1, ANAPC10, ANAPC4, ANAPC5, ANAPC7, CDC16, CDC20, CDC23, CDC27. Blood, Embryonic Tissue, Eye, Kidney, Liver, Muscle, Nerve, Ovary, Pancreas, Skin tissues are correlated with this protein. Adenocarcinoma, Infertility, Male, Kidney Diseases, Kidney Neoplasms, Learning Disorders, Memory Disorders, Neoplasms, Experimental, Urologic Neoplasms, Uterine Cervical Neoplasms, Uterine Neoplasms are some of the diseases may be linked to ANAPC2 antibody.