|The ALPL alpl (Catalog #MBS222650) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s ALKALINE PHOSPHATASE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).
ELISA: Minimum Dilution: 1/1500; Maximum Dilution: 1/15000. Researchers should empirically determine the suitability of the ALPL alpl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ALPL alpl product has the following accession number(s) (GI #116734717) (NCBI Accession #NP_000469.3) (Uniprot Accession #P05186). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Sheep anti Human alkaline phosphatase (Bap) antibody recognizes human bone alkaline phosphatase (BAP), a membrane-bound hydrolase enzyme expressed by osteoblast cells. Alkaline phosphatase (AP) is an ubiquitously expressed enzyme which removes phosphate groups from target molecules, including DNA, RNA and alkaloids, under alkaline conditions, and is present at higher concentrations in the placenta (placental AP), intestines (intestinal AP) and liver/bone/kidney (tissue non-specific AP). Although the exact biochemical function of BAP is uncertain, measurement of the serum levels of BAP can be used as a biochemical indicator of bone turnover. Conditions which present with a decrease in the level of BAP (hypophosphatasemia) include the inherited bone-deforming disorder hypophosphatasia and osteoporosis, whilst an increase in BAP (hyperphosphatasemia) is associated with Paget\'s disease, bone fractures and osteosarcomas.
Perservative Stabilisers: 0.09% Sodium Azide (NaN3). Immunogen: Alkaline phosphatase from human bone
Buffer Solution: Phosphate buffered saline
Antiserum Preparation: Antisera to human alkaline phosphatase were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G.
Target Species: Human. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ALPL are readily searchable from our website. Different antibodies against the same target such as ALPL may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Calcinosis, Cardiovascular Diseases, Hypertension, Hypertrophy, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Pain, Seizures are some of the diseases may be linked to SHEEP ANTI HUMAN ALKALINE PHOSPHATASE (BAP). Adipose Tissue, Blood, Bone, Brain, Connective Tissue, Embryonic Tissue, Kidney, Liver, Mouth, Skin tissues are correlated with this protein.