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anti-AICDA antibody product blog

Posted on 2014-08-02 12:23:20 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; AICDA; anti-AICDA antibody; Activation-induced cytidine deaminase;
The AICDA aid (Catalog #MBS622485) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Activation-induced Cytidine Deaminase can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC).
Suitable for use in ELISA, Western Blot, Immunocytochemistry.
Dilution: Western Blot: 1-2ug/ml. See Control Peptide, A0855-75J1.
Immunocytochemistry: 5-10ug/ml. Researchers should empirically determine the suitability of the AICDA aid for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The AICDA aid product has the following accession number(s) (GI #10190700) (NCBI Accession #NP_065712.1) (Uniprot Accession #Q546Y9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNAediting cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).


Immunogen: Synthetic peptide corresponding to 14 amino acids near the carboxy-terminus of human AID (GenBank accession no. AAM95402). Positive Control: Whole cell lysate from Ramos cells. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AICDA are readily searchable from our website. Different antibodies against the same target such as AICDA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Kidney, Lymph, Lymph Node, Pancreas, Pharynx, Tonsil tissues are correlated with this protein. AICDA also interacts with the following gene(s): RPA1. Adenocarcinoma, Arthritis, Rheumatoid, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2, Inflammation, Leukemia, Liver Neoplasms, Neoplasms, Stomach Neoplasms are some of the diseases may be linked to Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2).
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