anti-AGR2 antibody product blog
Tags: Antibody; AGR2; Polyclonal Antibody; anti-AGR2 antibody;
The AGR2 agr2 (Catalog #MBS620554) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The AGR2 (Anterior Gradient 2 Homolog (Xenopus laevis), AG2, GOB-4, HAG-2, XAG-2, Secreted Cement Gland Homolog) reacts with Canine, Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s AGR2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:128,000
Western Blot: 0.01 g/ml. Researchers should empirically determine the suitability of the AGR2 agr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The AGR2 agr2 product has the following accession number(s) (GI #5453541) (NCBI Accession #NP_006399.1) (Uniprot Accession #O95994). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the AGR2 (Anterior Gradient 2 Homolog (Xenopus laevis), AG2, GOB-4, HAG-2, XAG-2, Secreted Cement Gland Homolog) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of AGR2 in Human Duodenum lysate (35μg protein in RIPA buffer) using AGR2 antibody (0.01μg/ml).)
The anterior gradient protein-2 (AGR2) is a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. It has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells. Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells (1). Specifically, AGR2 may serve as an useful molecular marker and/or potential therapeutic target for hormone-responsive breast tumors (2). AGR2 expression promotes tumor growth in esophageal adenocarcinoma cells as well. Expression was detected in proliferating and differentiated intestinal cells of secretory lineage, suggesting that AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas (3).
Immunogen: Synthetic peptide corresponding to human AGR2. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing AGR2 are readily searchable from our website. Different antibodies against the same target such as AGR2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.