anti-ADM antibody product blog
Tags: Antibody; Adrenomedullin; Polyclonal Antibody; anti-ADM antibody; ADM;
The ADM adm (Catalog #MBS617127) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Adrenomedullin (ADML) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Adrenomedullin can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot., Recommended Dilution:, Western Blot: 1-10ug/ml using ECL., ELISA: 0.5-1ug/ml; A0909-40B: Control peptide can be used to coat ELISA plates at 1ug/ml., Optimal dilutions to be determined by the researcher., Storage and Stability:, May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Researchers should empirically determine the suitability of the ADM adm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ADM adm product has the following accession number(s) (GI #765330) (Uniprot Accession #P35318). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The calcitonin family of bioactive peptides comprises of calcitonin, amylin, two calcitonin-gene related peptides (CGRP1, and CGRP2) and adrenomedullin (ADML). Calcitonin is 32aa peptide found in the parafollicular "C" cells of the thyroid in mammals. It is also found in a number of non-mammals. It regulated the mineral (calcium and phosphate) balance. Calcitonin causes hypercalcemia by acting as an inhibitor of osteoclast induced bone resorption. CGRP is a 37aa peptide produced by tissue specific processing of the calcitonin gene. Calcitonin is the major product in the thyroid, whereas CGRP is the major product in neural tissues. CGRP is a potent cardiovascular agent. It has structural similarity with amylin. CGRP is found in two isoforms (CGRP-I and CGRP-II) that differs only by 3aa. Amylin is a 37aa peptide produced in the pancreatic beta-cell secretory granules and is co-released with insulin. Amylin also has CGRP-like effects on bone metabolism. Amylin has specific binding sites in the CNS and it may regulate gastric emptying and influence carbohydrate metabolism. Adrenomedullin (ADML) is a 52aa hypotensive peptide. It has structural similarity with CGRP and amylin. ADML is produced in peripheral tissues, adrenal medulla, lung, and kidney. ADML has specific receptors on astrocytes and it is unregulated in ischaemia. The calcitonin family peptides probably act through G-protein coupled membrane receptors. Recently, a homolog of calcitonin receptor, CRLR (calcitonin-receptor-like receptor human 461aa; rat/mouse 463aa) was identified. It is now shown that CRLR can function as either a CGRP receptor or an ADML receptor, depending upon which members of a new family of proteins called receptor activity modifying proteins (RAMP1-3) are expressed.