anti-ACVR2B antibody product blog
Tags: Antibody; Monoclonal Antibody; Activin Receptor Type IIB; anti-ACVR2B antibody; ACVR2B;
The ACVR2B acvr2b (Catalog #MBS605715) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Activin Receptor Type IIB (RIIB) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Activin Receptor Type IIB can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in Direct ELISA and Western Blot.
Dilution: Direct ELISA: 0.5-1.0ug/ml. The detection limit for recombinant human Activin RIIB is ~2ng/well.
Western Blot: 1-2ug/ml. The detection limit for recombinant human Activin RIIB is ~20ng/lane under reducing and non-reducing conditions. Researchers should empirically determine the suitability of the ACVR2B acvr2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACVR2B acvr2b product has the following accession number(s) (GI #5731735) (Uniprot Accession #Q13705). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, BMP-7, GDF-1, GDF-3, Myostatin (GDF-8), and GDF-11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.
Immunogen: Recombinant protein corresponding to the extracellular domain of human Activin RIIB, expressed in NSO cells. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACVR2B are readily searchable from our website. Different antibodies against the same target such as ACVR2B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Atrophy, Body Weight Changes, Breast Neoplasms, Carcinoma, Congenital Abnormalities, Craniofacial Abnormalities, Dextrocardia, Heart Defects, Congenital, Hepatitis, Lung Neoplasms are some of the diseases may be linked to Activin Receptor Type IIB (RIIB). ACVR2B also interacts with the following gene(s): ACVR1B, BMP2, BMP7, GDF11, INHBA, MSTN. The following patways have been known to be associated with this gene. Ear, Embryonic Tissue, Heart, Kidney, Lung, Mammary Gland, Ovary, Stomach, Testis, Uncharacterized Tissue tissues are correlated with this protein.