anti-Acvr2a antibody product blog
Tags: Antibody; Polyclonal Antibody; Activin Receptor Type IIA; anti-Acvr2a antibody; Acvr2a;
The Acvr2a acvr2a (Catalog #MBS621590) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Activin Receptor Type IIA (RIIA) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Activin Receptor Type IIA can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Neutralization.Suitable for use in Neutralization, ELISA, Western Blot and Immunohistochemistry.
Dilution: Neutralization: ~1-3ug/ml will block 50% of the binding of 30ng/ml recombinant human Activin A to immobilized recombinant human Act RIIA/Fc Chimera (100ul of a 0.5ug/ml solution was coated in each well) in a functional ELISA assay.
Direct ELISA: 0.5-1.0ug/ml. The detection limit is ~0.3ng/well.
Western Blot: 0.1-0.2ug/ml. The detection limit is ~5ng/lane and 25ng/lane under non-reducing and reducing conditions, respectively.
Immunohistochemistry (Paraffin): 15ug/ml for 5-15um thick sections. For detection of labeling, the ABC technique using chromogenic substrates is recommended. Researchers should empirically determine the suitability of the Acvr2a acvr2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Acvr2a acvr2a product has the following accession number(s) (GI #73853745) (NCBI Accession #NP_113759.1) (Uniprot Accession #P38444). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, Bmp7, Gdf1, Gdf3, Myostatin (Gdf8), and Gdf11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.
Immunogen: Sf 21-derived, recombinant human Activin RIIA extracellular domain. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Acvr2a are readily searchable from our website. Different antibodies against the same target such as Acvr2a may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Breast Neoplasms, Cardiovascular Diseases, Congenital Abnormalities, Craniofacial Abnormalities, Diabetes Mellitus, Type 2, Gonadal Disorders, Heart Defects, Congenital, Neoplasms, Osteoporosis, Osteoporosis, Postmenopausal are some of the diseases may be linked to Activin Receptor Type IIA (RIIA).