anti-Acvr2a antibody product blog
Tags: Antibody; Monoclonal Antibody; Activin Receptor Type IIA; anti-Acvr2a antibody; Acvr2a;
The Acvr2a acvr2a (Catalog #MBS606695) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Activin Receptor Type IIA (RIIA) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Activin Receptor Type IIA can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1ug/ml using human testis tissue. Researchers should empirically determine the suitability of the Acvr2a acvr2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Acvr2a acvr2a product has the following accession number(s) (GI #73853745) (NCBI Accession #NP_113759.1) (Uniprot Accession #P38444). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Activin Receptor Type IIA (RIIA) with the following immunoassay(s):
Western Blot (WB) (Western Blot detection of human Activin RIIA in lysates of human testis tissue using MBS606695. PVDF Membrane was probed with 1ug/ml of MBS606695 followed by IgG (HRP) anti-mouse secondary antibody. A specific band was detected for Activin RIIA at ~65kD (as indicated). This experiment was conducted under reducing conditions.)
Activin isoforms and other members of the TGFbeta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serinethreonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActRI(A), ActRIB, ActRII(A) and ActRIIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActRIIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different highaffinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptoractivin complex and initiate signal transduction. Besides the activin isoforms, ActRII will also bind inhibin, BMP2 and BMP7 with lower affinities. ActRI can also bind and form signaling complexes with the BMP2/7bound BMPRII. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.