anti-ACKR3 antibody product blog
Tags: Antibody; Polyclonal Antibody; ACKR3 / CXCR7 / RDC1; anti-ACKR3 antibody; ACKR3;
The ACKR3 ackr3 (Catalog #MBS241706) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7 reacts with Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, RatPredicted Reactivity: Xenopus (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. MyBioSource\'s ACKR3 / CXCR7 / RDC1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS).
Flo (1 - 10 ug/ml), IHC-P (10 ug/ml), WB (4 - 6 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the ACKR3 ackr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ACKR3 ackr3 product has the following accession number(s) (GI #31083344) (NCBI Accession #NP_064707.1) (Uniprot Accession #P25106). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-CXCR7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Western Blot (WB) (Western blot of human CXCR7/RDC1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using at 5 ug/ml.)
RDC1 was originally considered to be an Adrenomedullin receptor that binds calcitonin gene-related peptide (CGRP) and adrenomedullin. RDC1 and GPRN1 represent two tissue-specific subtypes of the same 60-kD receptor. RDC1 has the structural characteristics of a chemokine receptor. Recently it has been shown that RDC1 binds to the chemokine CXCL12 and should be considered to be a chemokine receptor.
Target Species: Human
Immunogen Description: A synthetic peptide (QHNQWPMGELTC) corresponding amino acids 106-117 of human CXCR7/RDC1 was used as the immunogen, GenBank NP_064707.1. Immunogen Type: Synthetic peptide
Immunogen: ACKR3 / CXCR7 antibody was raised against a synthetic peptide (QHNQWPMGELTC) corresponding amino acids 106-117 of human CXCR7/RDC1 was used as the immunogen, GenBank NP_064707.1. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Bat, Dog, Horse, Rabbit, Pig, Opossum (100%); Platypus, Xenopus (92%); Turkey (83%).
Antigen Modification: aa100-150. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ACKR3 are readily searchable from our website. Different antibodies against the same target such as ACKR3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.