AMICA1 blocking peptide product blog
Tags: Blocking Peptide; AMICA1; AMICA1 blocking peptide;
The AMICA1 jaml (Catalog #MBS9222589) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The AMICA1 jaml product has the following accession number(s) (GI #71151910) (NCBI Accession #Q86YT9.1) (Uniprot Accession #Q86YT9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction. Note: Localized at the plasma membrane and enriched in areas of cell-cell contacts. Tissue Location: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). Cardiovascular Diseases, Heart Diseases, Inflammation, Necrosis are some of the diseases may be linked to AMICA1 Antibody (N-term) Blocking Peptide. Blood, Brain, Heart, Intestine, Liver, Lymph Node tissues are correlated with this protein. The following patways have been known to be associated with this gene.