|The AMBP ambp (Catalog #MBS537043) is a Native Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s alpha 1 Microglobulin can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the AMBP ambp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The AMBP ambp product has the following accession number(s) (GI #579676) (NCBI Accession #CAA38587.1) (Uniprot Accession #P02760). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including alpha 1 Microglobulin are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Source Note: Urine from tubular proteinuria patients
Protein Type: Native
Biological Significance: A1M is a highly glycosylated protein of 27 kDa with a heterogenous charge which forms complexes with IgA and Albumin. High levels of A1M in urine are a good indicator of renal tubular dysfunction. Contaminants: None detected by SDS PAGE analysis. The following patways have been known to be associated with this gene. AMBP also interacts with the following gene(s): ALB, ITIH1, SERPINA1, SERPINC1. Brain, Embryonic Tissue, Heart, Intestine, Kidney, Liver, Lung, Muscle, Pancreas, Spleen tissues are correlated with this protein. Cardiovascular Diseases, Disease Models, Animal, Drug-Induced Liver Injury, Heart Diseases, Hemorrhage, Hypertension, Inflammation, Kidney Diseases, Liver Diseases, Necrosis are some of the diseases may be linked to alpha 1 Microglobulin protein.