ALOX12 blocking peptide product blog
Tags: Blocking Peptide; ALOX12; ALOX12 blocking peptide;
The ALOX12 alox12 (Catalog #MBS9227901) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The ALOX12 alox12 product has the following accession number(s) (GI #125987838) (NCBI Accession #P18054.4) (Uniprot Accession #P18054). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Cellular Location: Cytoplasm, cytosol. Membrane. Note: Membrane association is stimulated by EGF. Tissue Location: Expressed in vascular smooth muscle cells. The following patways have been known to be associated with this gene. Connective Tissue, Embryonic Tissue, Intestine, Lung, Muscle, Ovary, Skin tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Cardiovascular Diseases, Hypertension, Inflammation, Leukemia, Liver Diseases, Lung Diseases, Nervous System Diseases, Skin Diseases are some of the diseases may be linked to ALOX12 Antibody (C-term) Blocking Peptide.