ALK blocking peptide product blog
Tags: Blocking Peptide; ALK; ALK blocking peptide;
The ALK alk (Catalog #MBS9227037) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The ALK alk product has the following accession number(s) (GI #296439447) (NCBI Accession #Q9UM73.3) (Uniprot Accession #Q9UM73). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Cellular Location: Cell membrane; Single-pass type I membrane protein Note: Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. Tissue Location: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells. ALK also interacts with the following gene(s): EML4, MYC, NPM1, PIK3CA, PTN, SHC1, STAT3, TNFRSF8, ZC3HC1. Adenocarcinoma of lung, Carcinoma, Non-Small-Cell Lung, Chromosome Aberrations, Inflammation, Lung Diseases, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Large-Cell, Anaplastic, Neuroblastoma, Respiratory Tract Diseases are some of the diseases may be linked to ALK Antibody (C-term) Blocking Peptide. Blood, Brain, Connective Tissue, Liver, Muscle, Spleen, Stomach, Testis, Trachea, Uncharacterized Tissue tissues are correlated with this protein. The following patways have been known to be associated with this gene.